Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy
نویسندگان
چکیده
منابع مشابه
Extended Release of Timolol from Ethyl Cellulose Microparticles Laden Hydrogel Contact Lenses
Glaucoma is a second leading cause of blindness globally after cataract, which is managed through eye drops, which are highly inefficient due to a low bioavailability of less than 1-5%. Frequent administration of eye drops leads to incompliance in patients, so there is a great need for medical device such as contact lenses to treat glaucoma. The objective of research was to provide sustained oc...
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In this study, we compared, for the first time, the release of a 432 kDa prostaglandin F2a analogue drug, Latanoprost, from commercially available contact lenses using in vitro models with corneal epithelial cells. Conventional polyHEMA-based and silicone hydrogel soft contact lenses were soaked in drug solution (131 μg = ml solution in phosphate buffered saline). The drug release from the cont...
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Human eye is one of the most accessible organs in the body, nonetheless, its physiology and associated precorneal factors such as nasolacrimal drainage, blinking, tear film, tear turnover, and induced lacrimation has significantly decreased the residence time of any foreign substances including pharmaceutical dosage forms. Soft contact lenses are promising delivery devices that can sustain the ...
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ژورنال
عنوان ژورنال: Future Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 2314-7253
DOI: 10.1186/s43094-020-00128-9